Inflammation-Induced Cancer Conference
A joint scientific meeting of:
- The Israel Center of Research Excellence (I-CORE): Gene Regulation in Complex Human Disease, Israel
- The SFB/TRR77 – DFG, University of Heidelberg and MHH Hannover Medical School, Germany
- The SFB/841- DFG, University Medical Centre Hamburg-Eppendorf, Germany
- The Hadassah Hebrew University Hospital & the Hebrew University of Jerusalem, Israel
March 24-27, 2012
Hadassah Ein Kerem Auditorium, Hadassah Hebrew University Hospital, Jerusalem, Israel
Abstract submission period (only oral presentations): 15.12.11 – 15.1.12
Participation is free of charge!
The program will deal with the tools and readouts to investigate disease mechanisms, diagnostics and therapeutics, covering the following topics:
- The role of cytokines and downstream mediators in inflammation
- The role of chemokines and chemokine receptors in chronic inflammation and carcinogenesis
- The cellular immune and inflammatory cells involved in chronic inflammation
- The adoptive immune system in the chronic inflammatory state
- The DNA damage break responses in chronic inflammation
- The use of gene expression profiling in carcinogenesis
- The use of deep sequencing in chronic inflammation and carcinogenesis
- The use of advanced imaging tools for disease monitoring: intravital Confocal microscopy; microPET/CT and MRI for rodents
- The relevance of animal models
- Novel therapeutics; delivery of siRNAs; cytokine and chemokine antagonists
- Design of clinical studies in early and late stages of cancer, as well as prevention of cancer development
Top leading scientists in the field of cancer research from Israel, Germany, France, Spain, Italy,UK and the USA were invited to present their latest data. The meeting will also present cutting edge cancer research technologies including genetically engineered mice, ex-vivo tissue manipulation, novel imaging technologies, including molecule-targeted imaging and new techniques in the field of cancer-stem-cell research. The lectures will link innate and adaptive immunoregulatory mechanisms with carcinogenesis and cancer treatment by focusing on relevant basic research, preclinical, translational and clinical issues.
Download scientific program (PDF)
Saturday, March 24, 2012
19:30 RECEPTION
SESSION 1
Chairperson: Eithan Galun,HadassahHebrewUniversityMedicalCenter,Jerusalem,Israel
OPENING AND GREETINGS
19:45 – 19:55
Benjamin Geiger- Director of the ISF
19:55 – 20:00
Ehud Kokia – Director,HadassahHebrewUniversityMedicalCenter,Jerusalem,Israel
20:00 – 20:05
Eran Leitersdorf – Dean, Faculty of Medicine, HebrewUniversityofJerusalem,Jerusalem,Israel
SESSION 2
Chairpersons:
Peter Schirmacher, Heidelberg University Hospital, Heidelberg, Germany
Ansgar Lohse, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
20:10 – 20:55
Marie Annick Buendia, INSERM U785, Villejuif, France
Hepatitis B virus and liver cancer: control of viral transcription by the HBx protein and cellular factors
20:55 – 21:05
Musical performance: Idit Shemer, Genevieve Blanchard – Baroque flutes
W.F. Bach: Duo in F for 2 flutes. Allegro-Adagio-Vivace.
21:05 – 21: 50
Alberto Mantovani, University of Milan, Milan, Italy
Targeting cancer-related inflammation
Sunday, March 25, 2012
SESSION 3
Chairperson: Isaac P. Witz, Tel-AvivUniversity,Tel-Aviv,Israel
8:30 – 8:45
Ittai Ben-Porath, The HebrewUniversity ofJerusalem,Jerusalem,Israel
Controlled induction of cellular senescence in vivo
8:45 – 9:15
Chaim Cedar, The HebrewUniversity ofJerusalem,Jerusalem,Israel
DNA methylation in cancer
9:15 – 9:30
Tamar Geiger, Tel-Aviv University, Tel-Aviv, Israel
Deep proteomic analysis of breast cancer
9:30 – 9:45
Omri Bauer, Weizmann Institute of Science, Rehovot, Israel
Runx3 is essential for inflammation-mediated skin tumorigenesis
9:45 – 10:15
Amnon Peled, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Inflammation-induced hepatocellular carcinoma is dependent on CCR5
10:15 – 10:35 COFFEE BREAK
SESSION 4
Chairperson:Yosef Shaul, Weizmann Institute of Science,Rehovot,Israel
10:35 – 11:05
Marc Feldmann, University of Oxford, London, UK
Anti-TNF therapy in rheumatoid arthritis: Is there relevance for cancer therapy
11:05 – 11:35
Mathias Heikenwälder, Technische Universität München (TUM), Helmholtz Zentrum München, Munich, Germany
Distinct roles of CCR2 signaling in tumor cell extravasation
11:35 – 12:05
Stefan Rose-John, Christian-Albrechts-University, Kiel, Germany
Pro-and anti-inflammatory properties of cytokines: A matter of cleavage
12:05 – 13:00 LUNCH BREAK
13:00 – 13:15
Netta Sela-Passwell, Weizmann Institute of Science,Rehovot,Israel
Novel inhibitory anti-metalloprotease antibodies show therapeutic potential
13:15 – 13:45
Ofer Mandelboim, The Hebrew University of Jerusalem, Jerusalem, Israel
The protective and the destructive activity of the NKp46 killer receptor in liver fibrosis and in type 1 diabetes
13:45 – 14:00
Dirk Schmidt-Arras, Christian-Albrechts-University,Kiel,Germany
An oncogenic gp130 deletion mutant displays impaired maturation and induces an inflammatory phenotype in a transgenic mouse model
14:00 – 14:20 COFFEE BREAK
SESSION 5
Chairperson: Gisa Tiegs,University Medical CenterHamburgEppendorf,Hamburg,Germany
14:20 – 14:50
Mariano Barbacid, The Spanish National Cancer Research Center (CNIO), Madrid, Spain
The role of inflammation in the progression of pancreatic ductal adenocarcinoma
14:50 – 15:05
Gabriele Sass, University Medical CentreHamburg-Eppendorf,Hamburg,Germany
Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2ko mice
15:05 – 15:20
Stephan Singer, University Hospital Heidelberg, Heidelberg, Germany
Post-transcriptional regulation of select p53 target genes by the nuclear pore component Nup98 in hepatocellular carcinoma
15:20 – 15:35
Henning Wege, University Medical CenterHamburg-Eppendorf,Hamburg,Germany
Transformation of telomerase-immortalized human hepatocytes – early steps of hepatocarcinogenesis
15:35 – 16:05
Lars Zender,MHHHannoverMedicalSchool, Hannover andHZIHelmholtzCenter,Braunschweig,Germany
Senescence surveillance in hepatocellular carcinoma
Monday, March 26, 2012
SESSION 6
Chairperson: Snorri S. Thorgeirsson, National Institutes of Health (NIH), Bethesda, Maryland, USA
9:00 – 9:15
Carmit Levy, Tel-Aviv University, Tel-Aviv, Israel
The three M’s: Melanoma, MITF and microRNA
9:15 – 9:45
Michael Karin, UC San Diego, La Jolla, California, USA
New tricks for an old pony: IKKα and death-stimulated tumor progression
9:45 – 10:15
Hellmut G. Augustin ,DKFZGermanCancerResearchCenter,Heidelberg,Germany
Role of Angiopoietin/Tie signaling in inflammatory, angiogenic and tissue-regenerative signaling
10:15 – 10:30
Lars Wiechert,DKFZGermanCancerResearchCenter,Heidelberg,Germany
Function of the S100a8 and S100a9 protein complex in liver homeostasis and inflammation
10:30 – 10:50 COFFEE BREAK
SESSION 7
Chairperson: Stefan Rose-John, Christian-Albrechts University, Kiel, Germany
10:50 – 11:20
Michal Baniyash, The Hebrew University of Jerusalem, Jerusalem, Israel
Chronic inflammation-induced immunosuppression: Underlying mechanisms and clinical implication in cancer
11:20 – 11:35
Izhak Haviv,BarIlanUniversity,Ramat Gan,Israel
Distinguishing epithelial from stromal expression of mesenchymal signatures in cancer
11:35 – 11:50
Zvi G. Fridlender,HadassahHebrewUniversityHospital,Jerusalem,Israel
Tumor-associated neutrophils – evolution, phenotype, polarization and implications for anti-tumor immunity
11:50 – 12:20
Ron N. Apte,Ben-GurionUniversity of the Negev,Beer-Sheva,Israel
Interelukin-1-mediated inflammation and the malignant process
12:20 – 12:50
Eli Pikarsky, The Hebrew University of Jerusalem, Jerusalem, Israel
Acquisition of a pro-tumorigenic macrophage phenotype depends on c-Jun phosphorylation
12:50 – 13:20
Nisar Malek, University Hospital, Tübingen, Germany
Regulation of genetic stability through an ubiquitin ligase controlling centrosome duplication
13:20 – 14:00 LUNCH BREAK
SESSION 8
Chairperson: Tamar Peretz,HadassahHebrewUniversityMedicalCenter,Jerusalem,Israel
14:00 – 14:30
Yinon Ben-Neriah, The Hebrew University of Jerusalem, Jerusalem, Israel
Inflammatory control of colorectal cancer progression
14:30 – 15:00
Snorri S. Thorgeirsson, National Institutes of Health (NIH),Bethesda,Maryland,USA
Stem cells and cancer: A deadly attraction
15:00 – 15:15
Jorg Schrader, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Inflammation-induced extracellular matrix alteration in liver cancer
15:15 – 15:30
Ido Amit, Weizmann Institute of Science,Rehovot,Israel
Systematic mapping of temporal transcription factor binding reveals principles of mammalian gene regulation
15:30 – 16:00
Erwin F. Wagner, The Spanish National Cancer Research Center (CNIO), Madrid, Spain
Inflammation and cancer: Functions of AP-1 (Fos/Jun)
16:00 – 16:20 COFFEE BREAK
SESSION 9
Chairperson: Yinon Ben-Neriah, The Hebrew University of Jerusalem, Jerusalem, Israel
16:20 – 16:35
Helena Shaked,University ofCalifornia,San Diego,La Jolla,CA,USA
Epithelial NF-kB activation accelerates intestinal tumorigenesis through iNOS upregulation
16:35 – 16:50
Zeev Dvashi,TelAvivUniversity, TelAviv,Israel
Increased inflammation and angiogenesis in PPM1A KO mice
16:50 – 17:20
Jesus Gil, Imperial College London, London, UK
Non-cell-autonomous senescence
17:20 – 17:35
Florian Kühnel, MHH Hannover Medical School, Hannover, Germany
Breaking tolerance: virus infections in tumors and tumor-directed immune responses
Tuesday, March 27, 2012
SESSION 10
Chairperson: Johannes Herkel,University Medical CenterHamburgEppendorf,Hamburg,Germany
8:30 – 9:00
Yosef Shaul, Weizmann Institute of Science, Rehovot, Israel
Proteasomes in cancer cells – formation and activity
9:00 – 9:15
Kai Breuhahn, University Hospital Heidelberg, Heidelberg, Germany
Effector mechanisms of oncogenic YAP in gastrointestinal tumors
9:15 – 9:30
Rinat Abramovitch, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Double strand DNA breaks, chronic inflammation and liver cancer
9:30 – 9:45
Jonathan Axelrod, Hadassah Hebrew Medical Center, Jerusalem, Israel
Interleukin-6 is crucial for accelerated hepatocellular carcinogenesis following liver regeneration in a murine model of chronic inflammation-associated HCC
9:45 – 10:15
Kristoffer Weber, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
RGB marking with LeGO vectors for multi-color clonal cell tracking
10:15 – 10:45
Ralf Bartenschlager, Heidelberg University, Heidelberg, Germany
Hepatitis C virus and its role in promoting hepatocellular carcinoma
10:45 – 11:05 COFFEE BREAK
SESSION 11
Chairperson: Eli Pikarsky, The Hebrew University of Jerusalem, Jerusalem, Israel
11:05 – 11:20
Valery Krizhanovsky, Weizmann Institute of Science,Rehovot,Israel
Mechanisms of immune surveillance of senescent cells in liver fibrosis
11:20 – 11:35
Daniel Goldenberg, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Transgene expressing hepatitis C virus polyprotein efficiently promotes inflammation-induced hepatocarcinogenesis
11:35 – 11:50
Tomer Cooks, Weizmann Institute of Science,Rehovot,Israel
Mutant p53 prolongs NFkB activation and promotes chronic inflammation and inflammation-associated colorectal cancer
11:50 – 12:05
Daniel Dauch, Helmholtz Centre for Infection Research,Braunschweig,Germany
In vivo RNAi screening identifies new mediators of p53-independent tumor suppressive functions of p19Arf in the liver
12:05 – 12:20
Neta Erez, Tel Aviv University, Tel-Aviv, Israel
Cancer-associated fibroblasts mediate tumor promoting inflammation
12:20 – 12:45
David J. Waxman, Boston University, Boston, Massachusetts, USA
VEGF receptor inhibitors block the activation of innate immunity-induced tumor regression by metronomic chemotherapy
12:45 – 13:00
Erez Y. Levanon, Bar Ilan University, Ramat-Gan, Israel
RNA editing, as a mechanism for somatic mutations induced by inflammation
13:00 – 13:30
Adit Ben-Baruch Tel Aviv University, Tel Aviv, Israel
The inflammatory microenvironment in breast cancer: Regulation of a pro-angiogenic switch and cell-remodeling